FACTOR-V (ARG(506)-]GLN) MUTATION IN YOUNG SURVIVORS OF MYOCARDIAL-INFARCTION

Many young patients with venous thromboembolic disease are partially r esistant to the anticoagulant action of activated protein C as a resul t of factor V (Arg(506) --> Gln) mutation. The frequency of this mutat ion in young patients with arterial thrombotic diseases, such as myoca rdial infarction, is less well established. We studied 100 young patie nts with myocardial infarction and 100 age- and sex-matched controls. One patient (1%; 95% CL 0.05-6.2) and two controls (2%; 95% CL 0.3-7.7 ) were heterozygotes for the mutation; there was no homozygote in eith er group. Hence, premature myocardial infarction is not associated wit h heterozygosity for factor V (Arg(506) --> Gln) mutation.