INCREASE OF OCULAR BLOOD-FLOW BY SOME PHYTOGENIC COMPOUNDS

The effects of a number of phytogenic compounds on ocular blood now we re measured by the colored microsphere technique in rabbits. Methyltyr amine and coumarin increased blood now in all eye tissues tested. The blood now of iris, ciliary body-iris root, retina and choroid was incr eased by methyltyramine for 255%, 322%, 189%, and 189%, respectively, and by coumarin for 375%, 193%, 139% and 299%, respectively, at 120 mi nutes after drug administration. Rescinnamine, apocynin and hesperetin also increased ocular blood now in all eye tissues except retina. The blood now of iris, ciliary body-iris root, and choroid was increased by rescinnamine for 344%, 234%, and 199%, respectively; by apocynin fo r 355%, 152%, and 414%, respectively; and by hesperetin for 265%, 136% , and 204%, respectively, at 120 minutes after drug instillation. Thes e results indicate that these compounds could be used to treat ischemi c eye diseases in the future.