INHIBITORY EFFECTS OF INTERLEUKIN-1 BLOCKERS ORE CORNEAL FIBROBLAST PROLIFERATION

The regulation of wound healing is one of the most important fields of research in ophthalmology today. Rabbit corneal fibroblast cultures w ere used to study the effects of interleukin-1 (IL-1), blockers on the proliferation of fibroblasts which is closely related to the wound he aling. It was found that IL-1 blockers, such as CK-17, CK-101A, CK-102 and CK-103A, suppress fibroblast proliferation in a concentration-dep endent manner. DNA synthesis was significantly inhibited by CK-17 and CK-103A but not by CK-101A and CK-102. Although the synthesis of mRNA was reduced by all CK-compounds at most concentrations tested, the syn thesis of protein was only slightly reduced or unaffected. These resul ts indicate that CK-compounds are potent fibroblast inhibitors but not cytolytic agents.