IMPROVEMENT OF THE SYNTHESIS OF POLY(L-CYSTYL-L-CYSTINE) - A NEW BIODEGRADABLE POLYMER

Authors
BECHAOUCH S COUTIN B SEKIGUCHI H
Citation
S. Bechaouch et al., IMPROVEMENT OF THE SYNTHESIS OF POLY(L-CYSTYL-L-CYSTINE) - A NEW BIODEGRADABLE POLYMER, Macromolecular chemistry and physics, 197(5), 1996, pp. 1661-1668
Citations number
8
Categorie Soggetti
Polymer Sciences
Journal title
Macromolecular chemistry and physics → ACNP
ISSN journal
10221352
Volume
197
Issue
5
Year of publication
1996
Pages
1661 - 1668
Database
ISI
SICI code
1022-1352(1996)197:5<1661:IOTSOP>2.0.ZU;2-3
Abstract
A new synthesis of poly(L-cystyl-L-cystine) by using N,N'-bis(trimethy lsilyl)cystine dibenzyl ester is described. The polycondensation of th e latter with N,N'-bis(benzyloxycarbonyl)cystine bis(pentafluorophenyl ) ester allowed us to obtain polymers having higher molar masses (28 7 00 instead of 14 000 g/mol) and improved properties compared with earl ier methods. The partial as well as complete deprotection of the polym er using a new method, generally used in peptide chemistry, is also de scribed.