S. Bechaouch et al., IMPROVEMENT OF THE SYNTHESIS OF POLY(L-CYSTYL-L-CYSTINE) - A NEW BIODEGRADABLE POLYMER, Macromolecular chemistry and physics, 197(5), 1996, pp. 1661-1668
A new synthesis of poly(L-cystyl-L-cystine) by using N,N'-bis(trimethy
lsilyl)cystine dibenzyl ester is described. The polycondensation of th
e latter with N,N'-bis(benzyloxycarbonyl)cystine bis(pentafluorophenyl
) ester allowed us to obtain polymers having higher molar masses (28 7
00 instead of 14 000 g/mol) and improved properties compared with earl
ier methods. The partial as well as complete deprotection of the polym
er using a new method, generally used in peptide chemistry, is also de
scribed.