HORMONAL RESPONSES TO META-CHLOROPHENYLPIPERAZINE (M-CPP) ARE UNDIMINISHED BY ACUTE M-CPP PRETREATMENT

Authors
COCCARO EF KAVOUSSI RJ TRESTMAN RL GABRIEL SM COOPER TB SIEVER LJ
Citation
Ef. Coccaro et al., HORMONAL RESPONSES TO META-CHLOROPHENYLPIPERAZINE (M-CPP) ARE UNDIMINISHED BY ACUTE M-CPP PRETREATMENT, Psychiatry research, 62(2), 1996, pp. 139-145
Citations number
11
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
Psychiatry research → ACNP
ISSN journal
01651781
Volume
62
Issue
2
Year of publication
1996
Pages
139 - 145
Database
ISI
SICI code
0165-1781(1996)62:2<139:HRTM(A>2.0.ZU;2-L
Abstract
Two challenges with meta-chlorophenylpiperazine (m-CPP, 0.5 mg/kg, p.o .) were performed in healthy volunteers to test the short-term stabili ty of hormonal responses. Challenges were performed in an identical fa shion and were conducted on sequential days. Circulating m-CPP plasma levels, as well as prolactin and cortisol responses to m-CPP, were cor respondingly similar in magnitude on the 2 days. These data suggest th at both prolactin and cortisol responses to single oral administration s of m-CPP are stable over at least a 24-h period.