ISOLATION AND CHARACTERIZATION OF A BRADYKININ-POTENTIATING PEPTIDE (BPP-S) ISOLATED FROM SCAPTOCOSA-RAPTORIA VENOM

Authors
FERREIRA LAF ALVES WE LUCAS MS HABERMEHL GG
Citation
Laf. Ferreira et al., ISOLATION AND CHARACTERIZATION OF A BRADYKININ-POTENTIATING PEPTIDE (BPP-S) ISOLATED FROM SCAPTOCOSA-RAPTORIA VENOM, Toxicon, 34(5), 1996, pp. 599-603
Citations number
9
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
34
Issue
5
Year of publication
1996
Pages
599 - 603
Database
ISI
SICI code
0041-0101(1996)34:5<599:IACOAB>2.0.ZU;2-Q
Abstract
Venom of the spider Scaptocosa raptoria was fractionated by chromatogr aphy on Sephadex G-10 followed by HPLC, and a bradykinin potentiating peptide, BPP-S, was obtained in pure form. The amino acid sequence of this undecapeptide is presented. Peptide BPP-S significantly potentiat es the effects of bradykinin on smooth muscle, and inhibits the angiot ensin-converting enzyme (ACE) in vitro. Copyright (C) 1996 Elsevier Sc ience Ltd.