To accommodate topology change, the symmetry of space-time must be ext
ended from the diffeomorphism group of a manifold to the symmetric gro
up acting on the discrete set of space-time events. This is the princi
ple of event-symmetric space-time. I investigate a number of physical
toy models with this symmetry to gain some insight into the likely nat
ure of event-symmetric space-time. In the more advanced models the sym
metric group is embedded into larger structures such as matrix groups
which provide scope to unify space-time symmetry with the internal gau
ge symmetries of particle physics. I also suggest that the symmetric g
roup of space-time could be related to the symmetric group acting to e
xchange identical particles, implying a unification of space-time and
matter. I end with a definition of a new type of loop symmetry which i
s important in event-symmetric superstring theory.