THE 5TH-PLOT OF THE CARCINOGENIC POTENCY DATABASE - RESULTS OF ANIMALBIOASSAYS PUBLISHED IN THE GENERAL LITERATURE THROUGH 1988 AND BY THENATIONAL-TOXICOLOGY-PROGRAM THROUGH 1989
Ls. Gold et al., THE 5TH-PLOT OF THE CARCINOGENIC POTENCY DATABASE - RESULTS OF ANIMALBIOASSAYS PUBLISHED IN THE GENERAL LITERATURE THROUGH 1988 AND BY THENATIONAL-TOXICOLOGY-PROGRAM THROUGH 1989, Environmental health perspectives, 100, 1993, pp. 65-168
This paper is the fifth plot of the Carcinogenic Potency Database (CPD
B) that first appeared in this journal in 1984 (1-5). We report here r
esults of carcinogenesis bioassays published in the general literature
between January 1987 and December 1988, and in technical reports of t
he National Toxicology Program between July 1987 and December 1989. Th
is supplement includes results, of 412 long-term, chronic experiments
of 147 test compounds and reports the same information about each expe
riment in the same plot format as the earlier papers: the species and
strain of test animal, the route and duration of compound administrati
on, dose level and other aspects of experimental protocol, histopathol
ogy and tumor incidence, TD50 (carcinogenic potency) and its statistic
al significance, dose response, author's opinion about carcinogenicity
, and literature citation. We refer the reader to the 1984 publication
s (1,5,6) for a guide to the plot of the database, a complete descript
ion of the numerical index of carcinogenic potency, and a discussion o
f the sources of data, the rationale for the inclusion of particular e
xperiments and particular target sites, and the conventions adopted in
summarizing the literature. The rive plots of the database are to be
used together, as results of individual experiments that were publishe
d earlier are not repeated. In all, the five plots, include results of
4487 experiments on 1136 chemicals. Several analyses based on the CPD
B that were published earlier are described briefly, and updated resul
ts based on all five plots are given for the following earlier analyse
s: the most potent TD50 value by species, reproducibility of bioassay
results, positivity rates, and prediction between species. A new featu
re of this supplement is that Appendix 14 now provides a summary compe
ndium of positivity and potency, as well as an index to all chemicals
in the five plots of the CPDB. It provides the following summary data
for each chemical: (a) whether it has been tested in each sex of rats
and mice, and positivity results in each group; (b) for positive chemi
cals, a summary of carcinogenic potency for rats and for mice; (c) an
index to the CPDB sorted by chemical name that reports synonyms, CAS n
umber, and the plot numbers that include experiments on the chemical.
For readers using the CPDB more extensively, a combined plot of all re
sults from the five separate plot papers, ordered alphabetically by ch
emical is available from the first author in printed form or on comput
er tape or diskette. A SAS database is also available.