EFFECT OF TRAPIDIL DERIVATIVE AR-12456 ON INTRACELLULAR CHOLESTEROL HOMEOSTASIS IN HUMAN HEPATOMA-CELL LINE HEP-G2

Authors
CORSINI A GRIGNAFFINI P BEITZ J MEST HJ BELLOSTA S FUMAGALLI R PAOLETTI R
Citation
A. Corsini et al., EFFECT OF TRAPIDIL DERIVATIVE AR-12456 ON INTRACELLULAR CHOLESTEROL HOMEOSTASIS IN HUMAN HEPATOMA-CELL LINE HEP-G2, Cytotechnology, 11, 1993, pp. 15-17
Citations number
6
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Cytotechnology → ACNP
ISSN journal
09209069
Volume
11
Year of publication
1993
Supplement
1
Pages
15 - 17
Database
ISI
SICI code
0920-9069(1993)11:<15:EOTDAO>2.0.ZU;2-J
Abstract
The effect of trapidil derivative AR12456 on intracellular cholesterol metabolism was investigated in human hepatoma cell line HepG2. AR1245 6 enhanced the uptake and degradation of I-125-LDL in a dose-dependent manner. The drug inhibited cholesterol synthesis and esterification w ithout affecting cellular cholesterol content and bile acid synthesis; cholesterol efflux was slightly increased. These results show that th e inhibition of cholesterol synthesis together with the enhanced expre ssion of LDL receptors may partially explain the hypocholesterolemic a ctivity of compound AR12456.