POLYSEROSITIS AS AN UNUSUAL SIGN OF METHOTREXATE TOXICITY

We present a 46-year-old patient who underwent an abdominal hysterecto my with bilateral salpingo-oophorectomy for persistent trophoblastic d isease. Single-agent chemotherapy with alternate methotrexate 1 mg/kg/ day and leucovorin 0.1 mg/kg for 8 days was instituted on the first po stoperative day. Various adverse symptomatology developed, culminating in a unique side effect, polyserositis, To the best of our knowledge, the wide spectrum of side effects, the short lime lapse after onset o f chemotherapy, and their severity are uncommon in a patient receiving her first chemotherapeutic treatment with MTX. (C) 1996 Academic Pres s, Inc.