SOME EFFECT OF CUSO4 ON CARP

Copper treatment, muscle and liver accumulate a great amount of copper ions. The higher concentration of copper ions in the organism caused an elevated level of metallothionein. Copper induced the synthesis of metallothionein, mostly in the livers. In gel chromatography heat stab le low molecular weight protein certain coming from the destruction of high molecular weight proteins could be observed. On the effect of hi gher copper ion concentration in the liver, the level of the metalloth ionein bound to copper (as related to total protein bounded to copper) was decreased. This phenomenon shows the weaker affinity of apothione in to copper, compared to other proteins. Follows copper sulphate trea tment, every measured blood serum parameter was changed. GOT activity rose to 130% and the GPT to 300% of control. LDH activity increased, t oo. According to this, the anaerobic way became preferred in glucose m etabolism. On the effect of copper sulphate stress the blood serum glu cose concentration was higher than the control value.