PHOTODYNAMIC THERAPY OF TUMORS WITH HEXADECAFLUORO ZINC PHTHALOCYANINE FORMULATED IN PEG-COATED POLY(LACTIC ACID) NANOPARTICLES

Authors
ALLEMANN E ROUSSEAU J BRASSEUR N KUDREVICH SV LEWIS K VANLIER JE
Citation
E. Allemann et al., PHOTODYNAMIC THERAPY OF TUMORS WITH HEXADECAFLUORO ZINC PHTHALOCYANINE FORMULATED IN PEG-COATED POLY(LACTIC ACID) NANOPARTICLES, International journal of cancer, 66(6), 1996, pp. 821-824
Citations number
18
Categorie Soggetti
Oncology
Journal title
International journal of cancer → ACNP
ISSN journal
00207136
Volume
66
Issue
6
Year of publication
1996
Pages
821 - 824
Database
ISI
SICI code
0020-7136(1996)66:6<821:PTOTWH>2.0.ZU;2-R
Abstract
Hexadecafluoro zinc phthalocyanine (ZnPcF(16)), a second-generation se nsitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene-glycol-coated poly(lactic acid) nanoparticles (PEG-coa ted PLA-NP) and tested in EMT-6 tumour-bearing mice for its photodynam ic activity. The tumour response was compared to that induced by the s ame dye formulated as a Cremophor EL (CRM) emulsion. Formulation in th e biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT. (C) 1996 Wiley-Liss, Inc.