OXYGEN CONCENTRATION INFLUENCES PROTON PUMP INHIBITOR ACTIVITY AGAINST HELICOBACTER-PYLORI IN-VITRO

Omeprazole and lansoprazole are proton pump inhibitors that have shown activity against Helicobacter pylori and other Helicobacter species w hen tested by agar dilution. Lansoprazole was more active against H. p ylori than was omeprazole, and the activity was independent of urease production, Disk susceptibility tests and agar dilution MIC determinat ions were performed to investigate the effects of incubation under dif ferent sets of atmospheric conditions on H. pylori inhibition. Oxygen concentration was found to influence proton pump inhibitor activity in vitro, with higher concentrations leading to greater susceptibility, The method of testing is important in determining the anti-Helicobacte r activity of proton pump inhibitors.