EUKARYOTIC CELLS PROTECT BORRELIA-BURGDORFERI FROM THE ACTION OF PENICILLIN AND CEFTRIAXONE BUT NOT FROM THE ACTION OF DOXYCYCLINE AND ERYTHROMYCIN

Authors
BROUQUI P BADIAGA S RAOULT D
Citation
P. Brouqui et al., EUKARYOTIC CELLS PROTECT BORRELIA-BURGDORFERI FROM THE ACTION OF PENICILLIN AND CEFTRIAXONE BUT NOT FROM THE ACTION OF DOXYCYCLINE AND ERYTHROMYCIN, Antimicrobial agents and chemotherapy, 40(6), 1996, pp. 1552-1554
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
6
Year of publication
1996
Pages
1552 - 1554
Database
ISI
SICI code
0066-4804(1996)40:6<1552:ECPBFT>2.0.ZU;2-U
Abstract
Despite appropriate antibiotic treatment, Lyme disease patients may ha ve relapses or may develop chronic manifestations. The intracellular l ocation of Borrelia burgdorferi suggests that antibiotics that penetra te cells will have greater efficiency. Doxycycline or erythromycin was more effective than penicillin or ceftriaxone in killing B. burgdorfe ri when the organism was groan in the presence of eucaryotic cells.