SENSITIZATION OF BACTERIA TO DANOFLOXACIN BY TEMPERATE PROPHAGES

Danofloxacin (CP-76,136) is in a class of agents that inhibit DNA gyra se and trigger induction of the SOS response and temperate bacteriopha ges. Killing studies against the bovine pathogen Pasteurella haemolyti ca demonstrated that danofloxacin exhibits particularly rapid killing kinetics. Here, lysogenic Escherichia coli bearing lambda is found to be more sensitive to danofloxacin than nonlysogenic E. coli. Danofloxa cin exposure also induced a prophage in P. haemolytica. The potency of danofloxacin against lysogens is likely enhanced by this prophage ind uction.