S. Froshauer et al., SENSITIZATION OF BACTERIA TO DANOFLOXACIN BY TEMPERATE PROPHAGES, Antimicrobial agents and chemotherapy, 40(6), 1996, pp. 1561-1563
Danofloxacin (CP-76,136) is in a class of agents that inhibit DNA gyra
se and trigger induction of the SOS response and temperate bacteriopha
ges. Killing studies against the bovine pathogen Pasteurella haemolyti
ca demonstrated that danofloxacin exhibits particularly rapid killing
kinetics. Here, lysogenic Escherichia coli bearing lambda is found to
be more sensitive to danofloxacin than nonlysogenic E. coli. Danofloxa
cin exposure also induced a prophage in P. haemolytica. The potency of
danofloxacin against lysogens is likely enhanced by this prophage ind
uction.