NEW PROCEDURES FOR THE SYNTHESIS OF HETEROCYCLIC SUBSTITUTED AND 2,4-DIFUNCTIONALIZED PYRIMIDINES

Authors
MARTINEZ AG FERNANDEZ AH JIMENEZ FM MARTINEZ PJM MARTIN CA SUBRAMANIAN LR
Citation
Ag. Martinez et al., NEW PROCEDURES FOR THE SYNTHESIS OF HETEROCYCLIC SUBSTITUTED AND 2,4-DIFUNCTIONALIZED PYRIMIDINES, Tetrahedron, 52(23), 1996, pp. 7973-7982
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
23
Year of publication
1996
Pages
7973 - 7982
Database
ISI
SICI code
0040-4020(1996)52:23<7973:NPFTSO>2.0.ZU;2-B
Abstract
N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were cond ensed with cyano compounds in the presence of triflic anhydride (Tf(2) O) to yield heteroarylpyrimidines. 2,4-Difunctionalized pyrimidines we re obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)py rimidines with nucleophiles. Copyright (C) 1996 Published by Elsevier Science Ltd