A FEASIBILITY STUDY OF ACCELERATED POLYCHEMOTHERAPY WITH CISPLATIN, EPIDOXORUBICIN AND CYCLOPHOSPHAMIDE (PEG) IN ADVANCED OVARIAN-CANCER

Authors
PRONZATO P BERTELLI G VIGANI A VAIRA F
Citation
P. Pronzato et al., A FEASIBILITY STUDY OF ACCELERATED POLYCHEMOTHERAPY WITH CISPLATIN, EPIDOXORUBICIN AND CYCLOPHOSPHAMIDE (PEG) IN ADVANCED OVARIAN-CANCER, British Journal of Cancer, 73(11), 1996, pp. 1425-1427
Citations number
16
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
73
Issue
11
Year of publication
1996
Pages
1425 - 1427
Database
ISI
SICI code
0007-0920(1996)73:11<1425:AFSOAP>2.0.ZU;2-J
Abstract
We have evaluated the feasibility of an increase in dose intensity of the cisplatin, epidoxorubicin and cyclophosphamide (PEC) regimen, with granulocyte colony-stimulating factor (G-CSF) support, in 22 patients with advanced ovarian cancer. Twenty-one patients (95.4%) received si x cycles of treatment: of these, 13 (61.9%) were also able to repeal c ycles every 14 days as planned. Marrow toxicity was similar to that ob served during conventional treatments. No severe mucositis or thromboc ytopenia was observed. A clinical complete response was observed in 9 out of 16 evaluable patients (56.2%).