A PILOT-STUDY ON RISK-FACTORS AND P53 GENE-EXPRESSION IN COLORECTAL-CANCER

Of 311 colorectal cancers diagnosed in 1984-86 in the county of Osterg otland, Sweden, 179 were included in a case-control study, and, of the se, 70 were investigated using immunohistochemical staining for p53 ge ne mutations. Alcohol use as well as medication with hydralazine-conta ining antihypertensive drugs, but not heredity were associated with p5 3 staining. The study is offered to illustrate the possible value of i nvestigating molecularly defined tumour subtypes in relation to specif ic risk factors.