ALPHA-2-ADRENERGIC RECEPTOR ACTIVITY IN PORCINE ADIPOCYTES IS ANDROGEN AND AGE CELL-SIZE DEPENDENT

Authors
COUTINHO LL BERGEN WG ROMSOS DR MERKEL RA
Citation
Ll. Coutinho et al., ALPHA-2-ADRENERGIC RECEPTOR ACTIVITY IN PORCINE ADIPOCYTES IS ANDROGEN AND AGE CELL-SIZE DEPENDENT, Comparative biochemistry and physiology. Part A, Physiology, 105(2), 1993, pp. 333-339
Citations number
18
Categorie Soggetti
Physiology,Biology
Journal title
Comparative biochemistry and physiology. Part A, Physiology → ACNP
ISSN journal
10964940
Volume
105
Issue
2
Year of publication
1993
Pages
333 - 339
Database
ISI
SICI code
1096-4940(1993)105:2<333:ARAIPA>2.0.ZU;2-N
Abstract
1. Using epinephrine plus propranolol we demonstrated alpha-2 adrenerg ic receptor (alpha2AR) activity (49% inhibition of theophylline stimul ated lipolysis) in adipocytes of adult intact male pigs (61 kg body wt and 97 mum adipocyte diameter). 2. Dose titration with an alpha2AR an tagonist (yohimbine) confirmed alpha2AR associated activity. 3. No alp ha2AR activity was observed in younger male or castrated male pigs. 4. The inhibitory action on lipolysis via the alpha2AR in pigs is depend ent on androgen status and adipocyte size or age.