We studied 30 patients with postictal psychosis and compared them with
33 patients with acute interictal psychosis and 25 patients with chro
nic psychosis. All patients had either complex partial seizures (CPS)
or EEG temporal epileptogenic foci. Patients with postictal psychosis
had a high incidence of psychic auras and nocturnal secondarily genera
lized seizures. The most striking feature that distinguished postictal
psychosis from both acute interictal and chronic psychoses was phenom
enological: the relatively frequent occurrence of grandiose delusions
as well as religious delusions in the setting of markedly elevated moo
ds and feeling of mystic fusion of the body with the universe. In addi
tion, postictal psychosis exhibited few schizophreniform psychotic tra
its such as perceptual delusions or voices commenting. Reminiscence, m
ental diplopia, and a feeling of impending death were also fairly freq
uent complaints of patients with postictal psychosis. Interictal acute
psychosis and chronic epileptic psychosis were psychopathologically s
imilar. Although acute interictal and chronic epileptic psychoses coul
d simulate schizophrenia, postictal psychosis results in a mental stat
e quite different from that of schizophrenic psychosis.