NOVEL STRATEGIES FOR TREATMENT-RESISTANT DEPRESSION

This article describes a highly selective constellation of the more un ique strategies for managing the treatment-resistant patient. As each successive move down the treatment algorithm flowchart becomes necessa ry, the risk/benfit ratio may shift toward less well-substantiated, bu t still biologically informed, strategies. Although some of the more u nusual treatments described in this article represent minimally charte d territories, the more promising techniques deserve further explorati on.