The differential diagnosis of psychoses in children and adolescents en
compasses a wide range of disorders. The interpretation of psychotic s
ymptoms in these patients must consider age, developmental level, symp
tomatology, and etiology for an appropriate DSM-IV diagnosis. Previous
classifications of psychoses provided little information about the un
derlying processes or possible treatment. Clinical experience suggests
that psychotic manifestations in young patients are influenced by dev
elopmental stage and that eliciting target symptoms from a young patie
nt necessitates using and understanding the youth's language. Proper p
atient assessment demands interviews with family and collaborative sou
rces, as well as endocrine, metabolic, neurologic, infectious, and tox
icologic laboratory evaluations. Treatment involves interventions aime
d at all spheres of life. The prognosis and outcome are generally poor
in early-onset psychoses and are complicated by comorbidities.