DEXAMETHASONE DECREASES THE EXPRESSION OF RETINOIC ACID RECEPTORS (RARS) IN RAT-LIVER

Authors
PALLET V AUDOUINCHEVALLIER I HIGUERET D GARCIN H HIGUERET P
Citation
V. Pallet et al., DEXAMETHASONE DECREASES THE EXPRESSION OF RETINOIC ACID RECEPTORS (RARS) IN RAT-LIVER, Journal of steroid biochemistry and molecular biology, 57(3-4), 1996, pp. 161-165
Citations number
32
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Journal of steroid biochemistry and molecular biology → ACNP
ISSN journal
09600760
Volume
57
Issue
3-4
Year of publication
1996
Pages
161 - 165
Database
ISI
SICI code
0960-0760(1996)57:3-4<161:DDTEOR>2.0.ZU;2-B
Abstract
Although adrenalectomy was without effect on the expression of retinoi c acid (RA) receptors (RARs), administration of the glucocorticoid ana log dexamethasone (Dex) to both control and adrenalectomized rats redu ced the expression of these receptors in rat liver. This effect can be mainly attributed to the action of Dex on 4-hydroxylation of RA. Dex, by enhancing 4-hydroxylation of RA, reduces its intracellular concent ration thereby leading to a decreased expression of RARs, since RAR be ta, the main type of RARs in liver, are known to be up-regulated by RA . Copyright (C) 1996 Elsevier Science Ltd