MOLECULAR RECOGNITION OF ACYCLIC AMINES .1. COCRYSTALLIZATION OF 2,2'-(ETHYLENEDIOXY)DIETHYLAMINE WITH DICARBOXYLIC-ACIDS

X-Ray structures of three co-crystals of 2,2'-(ethylenedioxy)-diethyla mine, normally occuring in liquid phase, with two molecules of fumaric - 1a, maleic - 1b, and one molecule of adipic acid - 1d, have been de termined. Two conformations of the diamine molecule with different deg rees of folding have been found in the crystal. Very selective molecul ar recognition between diprotonated diamine 1 and dicarboxylic acid mo lecules was observed in three crystal structures. Aggregates being bui lding blocks of the cocrystals included one doubly protonated diamine molecule and six diacid molecules at different protonation levels, hyd rogen-bonded through carbonyl groups.