EARLY EFFECTS OF NEUTRON-GAMMA OR GAMMA-I RRADIATION ON THE GROUP TOXICITY OF (+) AMPHETAMINE IN MICE

Authors
MARTIN C JANODET D JOB A ESCHENBRENNER M FATOME M
Citation
C. Martin et al., EARLY EFFECTS OF NEUTRON-GAMMA OR GAMMA-I RRADIATION ON THE GROUP TOXICITY OF (+) AMPHETAMINE IN MICE, Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 316(5), 1993, pp. 508-512
Citations number
24
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie → ACNP
ISSN journal
07644469
Volume
316
Issue
5
Year of publication
1993
Pages
508 - 512
Database
ISI
SICI code
0764-4469(1993)316:5<508:EEONOG>2.0.ZU;2-T
Abstract
To better understand the mechanism of action of gamma and neutron radi ation on the dopaminergic system, the influence of the two irradiation modalities on the group toxicity of (+) amphetamine was studied in mi ce. Neutron-gamma irradiation (3.6-4.95 Gy) leads to an early toxicity reduction, while gamma-exposure (7-12 Gy) induces an increase in toxi city. This suggests that these two types of radiation induce different early effects on central dopaminergic system. Possible mechanisms are discussed.