EXPERIMENTAL HEMORRHAGE AND BLOOD COMPONENT TRANSFUSION IN HUMANS - NO CHANGE IN PLASMA-CONCENTRATION OF THROMBIN-ANTITHROMBIN COMPLEX AND PLASMIN-ANTIPLASMIN COMPLEX

The influence of haemorrhage and blood transfusion on primary haemosta sis, coagulation and fibrinolysis was investigated in ten healthy male volunteers. Acute loss of 10 % of the blood volume did not give any s ignificant alteration in thrombin- antithrombin III (TAT) complex and plasmin-alpha(2)-antiplasmin (PAP) complex levels compared with a cont rol series. The skin bleeding time with the Simplate II device was not altered after the 10 % blood loss. Acute loss of 10 % of blood volume followed by transfusion of packed red cells or stored plasma did not resulted in any significant change in bleeding time, TAT and PAP compl ex levels. It could be concluded that a controlled haemorrhage does no t give any detecable changes of the platelet dependent primary haemost asis, blood coagulation and fibrinolysis. Transfusion of one unit of p acked red cells or stored plasma does not seem to adversely affect the haemostasis.