Trophic factors influence the coordinated pre- and postnatal growth an
d the development of the gastrointestinal (GI) tract. Systemically as
well as enterally administered trophic factors have effects upon the G
I tract, several have the potential to be used therapeutically to enha
nce GI maturation and repair following injury. Gastrointestinal trophi
c factors in human milk play an important role in regulating the adapt
ive functional changes which accompany the transition to postnatal ent
eral feedings.