Systemically administered carbonic anhydrase inhibitors have been in c
linical use since the 1950's. Their use and side effects have been rev
iewed extensively. Our review summarizes the development of topically
administered carbonic anhydrase inhibitors in patients with glaucoma.
Moreover, it documents clinical trials leading to the present choice o
f dorzolamide (MK-507), which is now being reviewed for worldwide appr
oval for marketing by 1995.