P. Lillis et Im. Thompson, SHOULD ASYMPTOMATIC PROGRESSION FOLLOWING DEFINITIVE LOCAL TREATMENT FOR PROSTATE-CANCER BE TREATED, Hematology/oncology clinics of North America, 10(3), 1996, pp. 703
Asymptomatic progression following definitive therapy for prostate can
cer can take the form of a detectable prostate-specific antigen (PSA)
or local recurrence following radical prostatectomy or a rising PSA or
palpable recurrence following radiotherapy. Options for treatment inc
lude hormonal therapy, radiotherapy, salvage surgery, and experimental
therapies. Although such forms of treatment have known effects on int
ermediate endpoints, such as reduction of PSA, the overall effect on s
urvival and quality of life is uncertain.