OBJECTIVE: To identify factors related to free-flap coverage of lower
extremity fractures that are linked to a negative outcome. DESIGN: A c
hart review. SETTING: A large microsurgical referral centre. PATIENTS:
From 1981 to 1989, the records of all patients who underwent free-tis
sue transfer to the lower extremity with more than 1 year of follow-up
were selected. From this was drawn a subgroup of 49 patients (mean ag
e, 36 years) who had tibial fractures (55% were motor vehicle injuries
) and in almost all cases established soft-tissue or bony defects. The
y formed the study group. INTERVENTION: Free-flap transfer. OUTCOME ME
ASURES: Factors that might be associated with free-flap failure: mecha
nism of injury, grade of tibial fracture, history of smoking, diabetes
, peripheral vascular disease, ischemic heart disease, vascular compro
mise in the leg preoperatively, recipient artery used, type of anastom
osis, and hypertension or hypotension intraoperatively. RESULTS: Type
IIIB tibial fractures were the most frequent (67%) and carried a signi
ficantly (p = 0.02) higher risk of free-flap failure than other types
of fracture. Patients underwent a mean of four procedures before refer
ral for free-tissue transfer. The mean time from injury to flap covera
ge was 1006 days. Stable, long-term coverage of the free flaps was ach
ieved in 78% of patients. Wound breakdown was most often caused by rec
urrent osteomyelitis (65%). Seventy-four percent of the fractures heal
ed. The amputation rate was 10%. Four patients required repeat free-fl
ap transfer for limb salvage. CONCLUSION: Only the grade of tibial fra
cture could be significantly related to postoperative free-flap failur
e.