DISTRIBUTION OF PROTEIN-KINASE-C ISOENZYMES IN DIFFERENT CELLS OF THEHUMAN HAIR FOLLICLE

The formation, shedding and regulated growth of pigmented hair shafts results from a tightly controlled interaction of epithelial, mesenchym al and neuroectodermal cells. Soluble mediators such as growth factors or cytokines [1], acting in an auto- or paracrine fashion, and marker s of final keratinocyte differentiation such as transglutaminase [2] o r versican [3] are most likely involved during this process, An increa sing body of evidence has been accumulated regarding these factors, bu t knowledge about intracellular signaling within the hair follicle is still limited.