The foveal avascular zone was measured angiographically in 144 subject
s with diabetic retinopathy and 27 control subjects. Statistical signi
ficance was defined as P < 0.01. Quantitatively, the foveal avascular
zone was significantly smaller in control eyes (median = 0.405 mm2) th
an in eyes with diabetic retinopathy, and smaller in eyes with backgro
und diabetic retinopathy (BDR; median = 0.737 mm2) than in eyes with p
roliferative diabetic retinopathy (PDR; median = 0.866 mm2) and prepro
liferative diabetic retinopathy (PPDR; median = 1.001 mm2). Qualitativ
ely, the contour of the foveal avascular zone in diabetic retinopathy
was irregular (29.2% of eyes with diabetic retinopathy vs 3.7% of cont
rol eyes) with scattered round microaneurysms. Diabetic retinopathy is
characterized by an irregular, large foveal avascular zone with scatt
ered microaneurysms.