THE FREQUENCY OF IGG SUBCLASS DEFICIENCY IN CHILDREN WITH RECURRENT RESPIRATORY-INFECTIONS

We studied the frequency of IgG subclass deficiency in 61 children (ag es 1-7 years, mean 3.8 years) with recurrent respiratory tract infecti ons by using the radial immunodiffusion method. The overall frequency of IgG subclass deficiency was found to be 39.3 percent (24 patients). Among 26 children who had major immunoglobulin abnormalities, we foun d IgG subclass deficiency in 11 patients (42.3%). In children with nor mal immunoglobulin levels, the frequency of IgG subclass deficiency wa s 37.1 percent (13 patients).