SURFACTANT ADMINISTRATION TO THE HUMAN FETUS IN-UTERO - A NEW APPROACH TO PREVENTION OF NEONATAL RESPIRATORY-DISTRESS SYNDROME (RDS)

Citation
Ev. Cosmi et al., SURFACTANT ADMINISTRATION TO THE HUMAN FETUS IN-UTERO - A NEW APPROACH TO PREVENTION OF NEONATAL RESPIRATORY-DISTRESS SYNDROME (RDS), Journal of perinatal medicine, 24(2), 1996, pp. 191-193
Citations number
4
Categorie Soggetti
Obsetric & Gynecology",Pediatrics
ISSN journal
03005577
Volume
24
Issue
2
Year of publication
1996
Pages
191 - 193
Database
ISI
SICI code
0300-5577(1996)24:2<191:SATTHF>2.0.ZU;2-9
Abstract
Supplementary surfactant (80 mg in 1 ml) was administered intra-amniot ically in proximity of the fetal mouth to 4 preterm fetuses (28 to 32 wks) with immature amniotic fluid indexes and whose delivery was immin ent. Administration was preceded by a aminophylline infusion (loading dose of 240 mg and maintenance of 0.8 mg/kg/min) to the mother in orde r to elicit sustained fetal breathing movements. Following delivery by cesarean section, the absence of signs of respiratory distress in the infants along with a completely uneventful clinical course suggests t hat the present therapeutic approach has great potential for becoming a reliable option for the antenatal prevention of RDS.