ROLE OF LIPID-PEROXIDATION IN IRON-INDUCED CELLULAR CALCIUM OVERLOAD

Calcium overload is the common pathway leading to cell injury. The rol e of iron-induced lipid peroxidation in the modification of Ehrlich ca rcinoma cells calcium homeostasis has been studied. There is a lack of correlation between that modification and the value of lipid peroxida tion. The stability characteristics of low-mol-weight iron complexes a ffect lipid peroxidation and, to a lesser extent, cellular calcium upt ake. Lipid peroxidation appears not as a triggering factor of cellular calcium homeostasis modification, but as a concomitant phenomenon.