INOSITOL LIPID-MEDIATED INTRANUCLEAR SIGNALING - A COMPARATIVE-ANALYSIS OF INVIVO LABELING IN INTERFERON ALPHA-SENSITIVE AND ALPHA-RESISTANT DAUDI LYMPHOMA-CELLS

Authors
CATALDI A DIPRIMIO R LISIO R RANA RA ROBUFFO I BOSCO D MISCIA S
Citation
A. Cataldi et al., INOSITOL LIPID-MEDIATED INTRANUCLEAR SIGNALING - A COMPARATIVE-ANALYSIS OF INVIVO LABELING IN INTERFERON ALPHA-SENSITIVE AND ALPHA-RESISTANT DAUDI LYMPHOMA-CELLS, Cellular signalling, 5(3), 1993, pp. 331-336
Citations number
22
Categorie Soggetti
Biology
Journal title
Cellular signalling → ACNP
ISSN journal
08986568
Volume
5
Issue
3
Year of publication
1993
Pages
331 - 336
Database
ISI
SICI code
0898-6568(1993)5:3<331:ILIS-A>2.0.ZU;2-V
Abstract
Changes in inositol lipid and diacylglycerol metabolism have been anal ysed in Daudi lymphoma cells treated up to 24 h with human DNA recombi nant interferon alpha. Results showing a different response of nuclear phosphoinositides and diacylglycerol, compared to whole cells, sugges t that the intranuclear signalling system activated by interferon in D audi cells involves nuclear inositol lipid metabolism. A well-characte rized clone of Daudi cells selected for resistence to the antiprolifer ative action of interferon provided controls for the specificity of re sults.