Id. Smith et al., GLUTAMATE-RECEPTOR AGONIST INJECTIONS INTO THE DORSAL STRIATUM CAUSE CONTRALATERAL TURNING IN THE RAT - INVOLVEMENT OF KAINATE AND AMPA RECEPTORS, European journal of pharmacology, 301(1-3), 1996, pp. 7-17
Unilateral stimulation of glutamate receptors in the dorsal striatum o
f intact rats resulted in contralateral turning. Turning behavior was
recorded for 20 min following unilateral intrastriatal injections (0.5
mu l) in chronically cannulated rats. Kainate injections caused a dos
e-dependent increase in contralateral rotation that was blocked by the
glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (C
NQX). the action potential blocker tetrodotoxin, and by increasing dos
es of the dopamine receptor antagonist cis-flupenthixol. Injections of
lpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) also c
aused rotation that was blocked with co-injections of CNQX, tetrodotox
in or cis-flupenthixol. Neither CNQX nor tetrodotoxin injected alone c
aused turning. This effect is dopamine-dependent, and may result from
a kainate or AMPA-induced increase in dopamine release. Glutamate rece
ptor agonist injections into the striatum may cause contralateral turn
ing by degrading information in ascending cortical projections and may
further influence locomotion via basal ganglia output nuclei projecti
ons to the brainstem.