REPEATED NALTREXONE ADMINISTRATION ACCELERATES RESOLUTION OF MORPHINESOMATIC WITHDRAWAL SIGNS IN MORPHINE-DEPENDENT RATS

Authors
MUNTONI AL DIANA M GESSA GL
Citation
Al. Muntoni et al., REPEATED NALTREXONE ADMINISTRATION ACCELERATES RESOLUTION OF MORPHINESOMATIC WITHDRAWAL SIGNS IN MORPHINE-DEPENDENT RATS, European journal of pharmacology, 301(1-3), 1996, pp. 9-10
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
301
Issue
1-3
Year of publication
1996
Pages
9 - 10
Database
ISI
SICI code
0014-2999(1996)301:1-3<9:RNAARO>2.0.ZU;2-Y
Abstract
Morphine-dependent rats were divided into two subgroups. The first was allowed to develop a spontaneous withdrawal syndrome which was still present 33 h after the last morphine administration. The second subgro up received five injections of naltrexone. While the first two injecti ons of naltrexone precipitated a marked somatic withdrawal syndrome, s ubsequent naltrexone failed to worsen the somatic signs. 24 h after th e last morphine administration, naltrexone was completely ineffective. It is concluded that naltrexone shortens the duration of the morphine somatic withdrawal signs in dependent rats.