SYNTHESIS OF 2',3'-FUSED-(3.3.0) GAMMA-BUTYROLACTONE-NUCLEOSIDES AND COUPLING WITH AMINO-NUCLEOSIDES TO GIVE AMIDE-LINKED NUCLEOTIDE-DIMER ANALOGS

Authors
ROBINS MJ SARKER S XIE MQ ZHANG WJ PETERSON MA
Citation
Mj. Robins et al., SYNTHESIS OF 2',3'-FUSED-(3.3.0) GAMMA-BUTYROLACTONE-NUCLEOSIDES AND COUPLING WITH AMINO-NUCLEOSIDES TO GIVE AMIDE-LINKED NUCLEOTIDE-DIMER ANALOGS, Tetrahedron letters, 37(23), 1996, pp. 3921-3924
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
23
Year of publication
1996
Pages
3921 - 3924
Database
ISI
SICI code
0040-4039(1996)37:23<3921:SO2GAC>2.0.ZU;2-M
Abstract
Stereoselective hydrogenation of Wittig products obtained readily (via the 3'-ketones) from 2',5'-bis-O-(tert-butyldimethylsilyl)nucleosides provides efficient access to 2',3'-fused gamma-butyrolactone-nucleosi des that can be coupled with 5'-amino-nucleosides (2-hydroxypyridine c atalysis) to give amide-linked nucleotide-dimer analogues. (C) 1996 El sevier Science Ltd