Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol give
s heteroarylpropane-2,3-diols which are functionalized to the 3-O-dime
thoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacte
d with alkyl or aryl Grignard reagents and then phosphitylated to yiel
d 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used
for combinatorial oligomer synthesis. (C) 1996 Elsevier Science Ltd