SYNTHESIS OF PROPANE-2,3-DIOL COMBINATORIAL MONOMERS

Authors
ACEVEDO OL ANDREWS RS
Citation
Ol. Acevedo et Rs. Andrews, SYNTHESIS OF PROPANE-2,3-DIOL COMBINATORIAL MONOMERS, Tetrahedron letters, 37(23), 1996, pp. 3931-3934
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
23
Year of publication
1996
Pages
3931 - 3934
Database
ISI
SICI code
0040-4039(1996)37:23<3931:SOPCM>2.0.ZU;2-C
Abstract
Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol give s heteroarylpropane-2,3-diols which are functionalized to the 3-O-dime thoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacte d with alkyl or aryl Grignard reagents and then phosphitylated to yiel d 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis. (C) 1996 Elsevier Science Ltd