HYDRIDE REAGENTS FOR STEREOSELECTIVE REDUCTIVE AMINATION - AN IMPROVED PREPARATION OF 3-ENDO-TROPANAMINE

Authors
MCGILL JM LABELL ES WILLIAMS M
Citation
Jm. Mcgill et al., HYDRIDE REAGENTS FOR STEREOSELECTIVE REDUCTIVE AMINATION - AN IMPROVED PREPARATION OF 3-ENDO-TROPANAMINE, Tetrahedron letters, 37(23), 1996, pp. 3977-3980
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
23
Year of publication
1996
Pages
3977 - 3980
Database
ISI
SICI code
0040-4039(1996)37:23<3977:HRFSRA>2.0.ZU;2-H
Abstract
The reductive amination of substituted cyclohexanones with sodium tria cyloxyborohydrides derived from NaBH4 and various carboxylic acids pro vides highly diastereoselective conversions to protected axial amines. This method was applied to the stereoselective preparation of 3-endo- tropanamine. (C) 1996 Elsevier Science Ltd