A NEW CLASS OF BIS-OXAZOLINE LIGANDS FOR THE CU-CATALYZED ASYMMETRIC CYCLOPROPANATION OF OLEFINS

Authors
BEDEKAR AV ANDERSSON PG
Citation
Av. Bedekar et Pg. Andersson, A NEW CLASS OF BIS-OXAZOLINE LIGANDS FOR THE CU-CATALYZED ASYMMETRIC CYCLOPROPANATION OF OLEFINS, Tetrahedron letters, 37(23), 1996, pp. 4073-4076
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
23
Year of publication
1996
Pages
4073 - 4076
Database
ISI
SICI code
0040-4039(1996)37:23<4073:ANCOBL>2.0.ZU;2-7
Abstract
A set of new chiral bis-oxazolines, 5a-b and 6a-c, has been synthesise d from D and L-diethyl 2,3-O-isopropylidene tartrates and chiral amino alcohols. These ligands were found to be efficient in the Cu(I)-catal ysed asymmetric cyclopropanation of olefins. Bis-oxazolines of this ty pe based on readily available valine were found comparable with previo us ligands based on the more expensive ten-leucine. (C) 1996 Elsevier Science Ltd.