We report here the cDNA sequence of human hyaluronan synthase. The cDN
A clone was isolated from a human fetal brain cDNA library by screenin
g with a DNA probe generated from the coding sequence of murine hyalur
onan synthase. It contains a 2107 bp cDNA insert which is composed of
a 1629 bp open reading frame and a short segment of the 3'-untranslate
d region. Comparative analysis of the predicted coding region with the
murine hyaluronan synthase sequence indicates 84.4% and 96.0% identit
y in nucleotide sequence and amino acid sequences, respectively. North
ern analysis indicated that the gene was ubiquitously expressed in var
ious human tissues. (C) 1996 Academic Press, Inc.