Dysthymic disorder is defined as chronic depression of a mild to moder
ate degree for at least two years' duration. The disorder tends to be
underdiagnosed despite a prevalence of 5 to 15 percent in primary care
settings. Both the diagnosis and treatment of dysthymic disorder may
be complicated by a variety of comorbid psychiatric and medical condit
ions as well as chronic stressors. Treatment may be determined by the
accompanying comorbid condition. Antidepressant drugs are moderately e
fficacious in the treatment of dysthymia, with selective serotonin reu
ptake inhibitors preferred over tricyclic antidepressants. However, pa
tients may report oversensitivity to antidepressants, experience only
partial remission with treatment and suffer relapses. Adjunctive suppo
rt or psychodynamic psychotherapy should also be considered.