H. Brandenburg et al., CLINICAL-SIGNIFICANCE OF PLACENTA-CONFINED NONMOSAIC TRISOMY-16, American journal of obstetrics and gynecology, 174(5), 1996, pp. 1663-1664
Since the introduction of chorionic villi sampling in 1984 we have obs
erved five first-trimester cases of nonmosaic placenta confined trisom
y 16. At subsequent follow-up it appeared that all five had an adverse
maternal or fetal outcome. In three cases the mother had preeclampsia
. Two of the infants were born with multiple congenital abnormalities,
including tetralogy of Fallot. All children were growth retarded.