ACETYLSALICYLIC-ACID INHIBITION OF N-BUTYL-(4-HYDROXYBUTYL)NITROSAMINE-INDUCED BLADDER CARCINOGENESIS IN RATS

We examined the effect of acetylsalicylic acid (ASA) on n-butyl-(4-hyd roxybutyl)nitrosamine (BHBN)-induced bladder carcinogenesis in male Wi star rats. Of 29 rats that received 0.05% BHBN in their drinking water for 9 weeks, 8 developed bladder cancer. Only 1 out of 29 rats that r eceived 0.1% ASA in their diet for 20 weeks, including the period of B HBN consumption, developed a tumor. That difference is statistically s ignificant. Bladder weight was significantly higher in rats given BHBN than in controls and in rats given both BHBN and ASA. We conclude tha t ASA inhibits BHBN-induced bladder carcinogenesis.