STUDY OF TYROSINE-HYDROXYLASE AND NEUROPEPTIDERGIC INNERVATION OF THEHUMAN OBSTRUCTED PELVEOURETERAL JUNCTION IN 4 DIFFERENT PATIENTS

Tyrosine hydroxylase and neuropeptidergic innervations of the obstruct ed pelveoureteral junctions of four different patients were investigat ed by immunohistochemical methods. A dense innervation of tyrosine hyd roxylase- and neuropeptide Y-nerves was found especially in the pelveo ureteral junction, which was congenitally obstructed, compared to othe rs found later (13- and 23-year old females). Also quite numerous vaso active intestinal polypeptide-nerves were seen as well as some calcito nin gene-related peptide-, galanin- and substance P-nerves in the musc ular layer of ureter. The innervation pattern of the obstructed pelveo ureteral junction of the horseshoe kidney was found to be normal.