Vg. Vanommen et al., COMPARISON OF ARTERIAL-WALL REACTION AFTER PASSAGE OF THE HYDROLYSER DEVICE VERSUS A THROMBECTOMY BALLOON IN AN ANIMAL-MODEL, Journal of vascular and interventional radiology, 7(3), 1996, pp. 451-454
PURPOSE: This study was designed to compare the reaction of the vessel
wall after application of the Hydrolyser hydrodynamic thrombectomy de
vice to the reaction after use of a balloon thrombectomy catheter. The
influence of the vessel inner diameter on vessel wall reaction was ev
aluated after passage of the Hydrolyser. MATERIALS AND METHODS: After
measurement of the vessel inner diameter with intravascular ultrasound
(US), 102 segments of femoral and carotid arteries of goats were trea
ted with one of the following four procedures: passage of the intravas
cular US catheter alone; passage of the Hydrolyser without or with an
activated jet; or passage of an inflated thrombectomy balloon. Histolo
gic evaluation was performed after 3 weeks. RESULTS: Intimal thickenin
g (more than five cell layers of neointima) 3 weeks after treatment oc
curred more frequently after passage of the balloon than after any of
the other procedures (P <.001). For vessels with a diameter of 3-4 mm,
4-5 mm, or more than 5 mm, no significant difference in vessel wall r
eaction was observed following Hydrolyser passage. CONCLUSION: In this
model, passage of the Hydrolyser device resulted in less intimal reac
tion compared with the thrombectomy balloon.