Pk. Sanyal et Sc. Gupta, EFFICACY AND PHARMACOKINETICS OF TRICLABENDAZOLE IN BUFFALO WITH INDUCED FASCIOLIASIS, Veterinary parasitology, 63(1-2), 1996, pp. 75-82
A study was conducted to understand pharmacokinetics and flukicidal ac
tivity of intraruminal administration of triclabendazole (TCBZ) at 12.
0, 24.0 and 36.0 mg kg(-1) body weight in experimentally Fasciola giga
ntica-infected buffaloes on Week 2 and 10 post-infection. No fluke egg
s in faeces and no flukes could be recovered from the liver of buffalo
es following intraruminal administration of triclabendazole at 24.0 an
d 36.0 mg kg(-1) body weight both on Weeks 2 and 10 post-infection, wh
ile the recommended therapeutic dose at 12.0 mg kg(-1) body weight was
19-23% effective. Pharmacokinetic analysis of the data revealed a sig
nificantly higher (P < 0.05) concentration maximum of both the metabol
ites and area under concentration-time curve of TCBZ-SO2 in animals tr
eated at 12.0 mg k(-1) body weight on Week 10 post-infection, whereas
a significantly higher area under the concentration-time curve and eli
mination half-life of both the metabolites and significantly higher co
ncentration maximum and area under the concentration-time curve of bot
h the metabolites were observed in animals treated on Week 10 post-inf
ection at the dose rates of 24.0 and 36.0 mg kg(-1) body weight, respe
ctively. Bioavailability of triclabendazole was more in buffaloes with
mature flukes than with immature flukes.