BIOAVAILABILITY AND PHARMACOKINETICS OF IBUPROFEN IN THE BROILER CHICKEN

The intravenous, intramuscular and oral pharmacokinetics of ibuprofen in broiler chickens were investigated, In a preliminary study, plasma ibuprofen concentration-time profiles, following i.v. (25 mg/kg) dosin g were best described by a 2-compartment model, After intravenous admi nistration, the volume of distribution at steady-state (V-d(ss)), the total systemic clearance (Cl-B), the elimination half-life (t(1/2B)) a nd the MRT were 0.303 L/kg, 482.3 ml/h . kg, 2.71 h and 1.02 h, respec tively. After intramuscular administration of ibuprofen, the t(max) an d C-max were 0.37 h, and 42.2 mu g/mL, respectively, with an estimated bioavailability of 46.7%. After oral administration of ibuprofen, the t(max) and C-max were 0.31 h and 23.91 mu g/mL, respectively, with an estimated bioavailability of 24.2%. This is a preliminary study, exam ining the use of ibuprofen in broiler chickens, and should be followed by tissue residue and efficacy studies in different disease states.